STAR LIGHT STUDY: XBB.1.5 COVID-19 MRNA VACCINES BOOST SYSTEMIC BUT NOT MUCOSAL IMMUNITY AGAINST THE SARS-COV-2 JN.1 VARIANT IN PATIENTS WITH CHRONIC LIVER DISEASE

Background: Patients with chronic liver disease (CLD) have impaired vaccine immunogenicity and an excess risk of severe COVID-19.While variant-adapted COVID-19 mRNA vaccines are recommended for vulnerable individuals, their efficacy in patients with CLD has not been studied.Methods: We present the first evaluation of XBB.1.5 COVID-19 vaccine immuno

This research addresses the problems related to gambling in the New Spain mining Nails cities.We refer, in great lines, to the characteristics of working conditions in relation to the good luck in finding rich minerals.We also deal with amusements, pastimes, and dedicated time to leisure.We study the passion that gambling generated and the existenc

The present-day networked media ecosystem is distinctly characterized by convergence.Recently, media convergence has experienced rapidly progress both in theoretical circles and in practical applications, and convergence development has inevitably become a leading trend in media development.Media convergence has uniquely transformed the ecology of

This review summarizes the research progress in the co-delivery of natural products (NPs) and small RNAs in cancer therapy.NPs such as paclitaxel, camptothecin, and curcumin possess multi-target antitumor effects, but their applications are limited by drug resistance and non-specific distribution.Small RNAs can achieve precise antitumor effects thr

Paul Arjanto,1 Mint Husen Raya Aditama,2 7-OH Vando Kristi Makaruku3 1Department of Educational Management, Pattimura University, Kota Ambon, Indonesia; 2Department of Guidance Nails and Counseling, Manado State University, Kabupaten Minasaha, Indonesia; 3Department of Educational Administration, Pattimura University, Kota Ambon, IndonesiaCorrespon